GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs7524495 | chr1:46266932 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -6.99 | 1.19E-11 | Body mass index |
| BLCA | cis | rs78153629 | 1 | rs75278386 | chr15:40678312 | C15orf23 | chr15:40674922-40686488:+ | 0.33 | 5.7 | 2.34E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs7528684 | 1 | rs7528684 | chr1:157670816 | FCRL3 | chr1:157646278-157670775:- | 0.26 | 8.49 | 4.56E-16 | Type 1 diabetes autoantibodies |
| BLCA | cis | rs7589728 | 1 | rs75309929 | chr2:88524377 | THNSL2 | chr2:88469835-88486145:+ | -0.57 | -5.69 | 2.53E-8 | Plasma clusterin levels |
| BLCA | cis | rs1466788 | 1 | rs7531202 | chr1:110616474 | ALX3 | chr1:110602998-110613322:- | -0.21 | -3.87 | 0.000129 | Blood metabolite levels |
| BLCA | cis | rs4660306 | 1 | rs7534467 | chr1:45988691 | CCDC163P | chr1:45960581-45965646:- | -0.79 | -16.21 | 2.35E-45 | Homocysteine levels |
| BLCA | cis | rs4660306 | 1 | rs7536557 | chr1:45992114 | CCDC163P | chr1:45960581-45965646:- | -0.73 | -14.77 | 2.15E-39 | Homocysteine levels |
| BLCA | cis | rs2275426 | 1 | rs7539932 | chr1:46292354 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs1144333 | 1 | rs75399471 | chr1:76339092 | RABGGTB | chr1:76251886-76260764:+ | 0.4 | 4.24 | 2.8E-5 | Attention function in attention deficit hyperactive disorder |
| BLCA | cis | rs2275426 | 1 | rs7540325 | chr1:46338217 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs6951245 | 1 | rs75488469 | chr7:1102122 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.48 | 9.73E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2275426 | 1 | rs7550746 | chr1:46351719 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.15E-11 | Body mass index |
| BLCA | cis | rs1077514 | 1 | rs7551124 | chr1:23785760 | ASAP3 | chr1:23755056-23811057:- | 0.3 | 4.25 | 2.66E-5 | Cholesterol, total |
| BLCA | cis | rs1077514 | 1 | rs7551124 | chr1:23785760 | TCEA3 | chr1:23707555-23751261:- | 0.33 | 4.51 | 8.49E-6 | Cholesterol, total |
| BLCA | cis | rs2275426 | 1 | rs7556436 | chr1:46363880 | CCDC163P | chr1:45960581-45965646:- | 0.37 | 7.12 | 5.27E-12 | Body mass index |